Transjugular Intrahepatic Portosystemic Shunt (TIPS)¶
Pakinam Mekki
Background¶
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A Transjugular Intrahepatic Portosystemic Shunt or TIPS procedure is done by interventional radiology to manage sequelae of portal hypertension (specifically variceal bleeding and ascites)
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A low-resistance shunt is created between an intrahepatic branch of the portal vein and the hepatic vein, allowing blood to bypass the high-resistance vessels within the fibrotic liver
Evaluation¶
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Indications for TIPS
- Variceal hemorrhage (esophageal, gastric, etc.)
- Early “preemptive” TIPS is an urgent TIPS placement within 72 hrs (preferably within 24 hours) of initial endoscopic hemostasis in pts at high risk for rebleeding (Child-Pugh Class B with active bleeding upon insertion of endoscope or Child-Pugh Class C with recent bleeding
- “Rescue” TIPS is placed in pts with active, uncontrolled variceal bleeding or if bleeding recurs despite maximal endoscopic and pharmacologic therapy
- Refractory ascites (prolongs survival)
- Other: portal hypertensive gastropathy, PVT recanalization, Budd-Chiari syndrome, hepatic hydrothorax
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Contraindications to TIPS
- Absolute contraindications
- Primary prevention of variceal bleeding, congestive heart failure, severe tricuspid regurgitation, severe pulmonary hypertension, multiple hepatic cysts or masses, Sepsis, unrelieved biliary obstruction
- Relative contraindications
- Hepatic encephalopathy, hepatic tumors (especially if centrally located), thrombocytopenia, moderate pulmonary hypertension
- Absolute contraindications
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Pre-procedure preparation
- Labs: CBC, CMP, INR
- Liver imaging to assess portal system patency and exclude liver masses
- Ideally triple phase CT with contrast
- In pts with renal impairment or active variceal bleeding, RUQ U/S with doppler is acceptable
- TTE to evaluate for evidence of congestive heart failure, pulmonary hypertension, or valvular disease.
- Antibiotic ppx with ceftriaxone 1g IV once at the time of TIPS insertion as enteric bacteria within the static portal system can enter systemic circulation
- Patients with HE should receive rifaximin prophylaxis starting 2 weeks before procedure
Management Post-TIPS¶
- Immediately following TIPS, pts are observed in the hospital overnight for complications
- Monitor CBC and vitals closely. If hemodynamically unstable, STAT CBC and low threshold to obtain CTA A/P to evaluate for a bleeding source
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TIPS causes a substantial increase in venous return to the heart, which can unmask cardiac dysfunction that was previously compensated for
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Obtain RUQ U/S with Doppler to assess shunt patency 1 month of TIPS placement, or if ascites and/or variceal hemorrhage reoccur
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If patient with a TIPS develops refractory HE, can consider TIPS revision to lessen HE symptoms