Fatigue¶
Thomas Horton
Background¶
- 21-33% of primary care patients describe fatigue as an important problem (even if not CC)
- Obtain a thorough history and validate the patient's concerns
- Assess impact on daily life and accommodations the patient has made to cope
- Description of fatigue: mental vs. physical; sleepiness/tiredness vs. "low energy"
- Assess Chronicity: Acute <1 month; subacute 1-6 months; Chronic >6 months
- Review medication list, age -elated cancer screening, prior lab values, imaging findings if applicable
- Brief Fatigue Inventory or Fatigue Assessment Scale can be used for quantification
Common Etiologies¶
System | Differential |
---|---|
Cardiopulmonary | CHF, CAD/Angina, PVD, Obstructive lung disease, OSA, other sleep-related disorders |
Endocrine | Diabetes, hypothyroidism, adrenal insufficiency, electrolyte abnormalities |
Hematologic/Neoplastic | Anemia, occult malignancy |
Infectious Disease | HIV, Mononucleosis, Hepatitis, other viral, TB, fungal, parasitic |
Medication Use | Opioids, benzodiazepines, antihistamines, muscle relaxants, anti-depressants, beta-blockers, GABA analogues, substance use (ETOH, THC, Cocaine) |
Psychological | Depression, anxiety, somatization disorder, dysthymia |
Rheumatologic | Fibromyalgia, PMR, SLE, RA, Sjögren's |
Evaluation¶
- Complete physical exam
- Lab tests to order if >1 month duration: CMP, CBC w/ diff, HIV, Hepatitis B/C, TSH
- Autoimmune, inflammatory, pregnancy, CK, PPD tests based on clinical context
- Assess for mood disorder (PHQ-9; GAD7)
- Assess for sleep disturbance (STOP-BANG, Epworth Sleepiness Scale)
- Age appropriate cancer screening if applicable
- Diagnostic imaging studies based on history and physical exam findings
- Screen for domestic violence, housing insecurity, substance use
Management¶
- Treatment is largely specific to underlying etiology of fatigue (if found)
- Etiology may never be identified
- Consider diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) if other causes have been ruled out
- Continue a supportive relationship with patient
- Consider empiric trial of antidepressant therapy in those with residual/idiopathic fatigue with depressed mood even if patient does not meet MDD criteria
Last update:
2022-07-05 15:04:16