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Joint Infections and Osteomyelitis – VASP


  • Blood cultures prior to antibiotics

  • MRI is the most sensitive and specific imaging modality for osteomyelitis.

  • Ortho consult for joint fluid aspirate or bone bx; send for culture and send fluid for cell count/differential.


  • Hold antibiotics until culture obtained, if patient is clinically stable

  • Osteomyelitis is a 6-week treatment course, can consider early transition (at 2-3 weeks) to oral if good bioavailability and susceptibility.

  • For prosthetic joint infection, procedure/retention of hardware determines duration

  • First line empiric: Vancomycin + ciprofloxacin 750mg BID

  • Antimicrobial therapy will ultimately be guided by culture data, ID consult recommended for joint infection treatment due to need for prolonged antibiotic therapy

Last update: 2022-06-21 22:15:25